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lymphocytes

Multiple Site Place-of-Care Manufactured Anti-CD19 CAR-T Cells Induce High Remission Rates in B Cell Malignancy Patients

[Nature Communications] The authors developed an anti-CD19 CAR comprised of the 4-1BB co-stimulatory and TNFRSF19 transmembrane domains, showing anti-tumor efficacy in an in vivo xenograft lymphoma model.

Foxp3+ CD4+ Regulatory T Cells Control Dendritic Cells in Inducing Antigen-Specific Immunity to Emerging SARS-CoV-2 Antigens

[PLoS Pathogens] Investigators examined the effect of transient breakdown of the immunological tolerance induced by Treg-cell depletion on adaptive immune responses against administered SARS-CoV-2 antigen, spike protein 1.

Endothelial Dysfunction Contributes to Severe COVID-19 in Combination with Dysregulated Lymphocyte Responses and Cytokine Networks

[Signal Transduction and Targeted Therapy] The authors combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.

Virus-Stimulated Dendritic Cells Elicit a T Antiviral Transcriptional Signature in Human CD4+ Lymphocytes

[Journal of Molecular Biology] Scientists identified a transcriptional signature associated with progressive resistance to HIV infection in CD4+ T cells.

NFAT-Dependent and -Independent Exhaustion Circuits Program Maternal CD8 T Cell Hypofunction in Pregnancy

[Journal of Experimental Medicine] Scientists used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells, which associated with prolonged allograft survival.

Early-Life Imprinting of Unconventional T Cells and Tissue Homeostasis

[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.

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