Tag results:
lymphocytes
Cell Therapy News
Multiple Site Place-of-Care Manufactured Anti-CD19 CAR-T Cells Induce High Remission Rates in B Cell Malignancy Patients
[Nature Communications] The authors developed an anti-CD19 CAR comprised of the 4-1BB co-stimulatory and TNFRSF19 transmembrane domains, showing anti-tumor efficacy in an in vivo xenograft lymphoma model.
Immunology of Infectious Disease News
Foxp3+ CD4+ Regulatory T Cells Control Dendritic Cells in Inducing Antigen-Specific Immunity to Emerging SARS-CoV-2 Antigens
[PLoS Pathogens] Investigators examined the effect of transient breakdown of the immunological tolerance induced by Treg-cell depletion on adaptive immune responses against administered SARS-CoV-2 antigen, spike protein 1.
Immunology of Infectious Disease News
Endothelial Dysfunction Contributes to Severe COVID-19 in Combination with Dysregulated Lymphocyte Responses and Cytokine Networks
[Signal Transduction and Targeted Therapy] The authors combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.
Immunology of Infectious Disease News
Virus-Stimulated Dendritic Cells Elicit a T Antiviral Transcriptional Signature in Human CD4+ Lymphocytes
[Journal of Molecular Biology] Scientists identified a transcriptional signature associated with progressive resistance to HIV infection in CD4+ T cells.
Immune Regulation News
NFAT-Dependent and -Independent Exhaustion Circuits Program Maternal CD8 T Cell Hypofunction in Pregnancy
[Journal of Experimental Medicine] Scientists used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells, which associated with prolonged allograft survival.
Immune Regulation News
Early-Life Imprinting of Unconventional T Cells and Tissue Homeostasis
[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.