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lymphocytes

Role of PD-L1 in Licensing Immunoregulatory Function of Dental Pulp Mesenchymal Stem Cells

[Stem Cell Research & Therapy] Direct and indirect co-cultures between dental pulp stem cells (DPSCs) and peripheral blood mononuclear cells (PBMCs) were carried out to evaluate the activation of immunomodulatory checkpoints in DPSCs and the inflammatory pattern in PBMCs.

Identification of Alpha-Enolase as a Potential Immunogenic Molecule during Allogeneic Transplantation of Human Adipose-Derived Mesenchymal Stromal Cells

[Cytotherapy] The allorejection of MSCs indicates that they are not fully immune-privileged. The authors investigated the immunogenicity of human adipose-derived MSCs and identified potential immunogenic molecules.

Abnormal Cannabidiol Ameliorates Inflammation Preserving Pancreatic Beta Cells in Mouse Models of Experimental Type 1 Diabetes and Beta Cell Damage

[Biomedicine & Pharmacotherapy] Scientists investigated whether Abn-CBD can modulate the inflammatory response during type 1 diabetes (T1D) onset using a mouse model of T1D and of beta cell damage.

Tumor-Associated Macrophages Promote PD-L1 Expression in Tumor Cells by Regulating PKM2 Nuclear Translocation in Pancreatic Ductal Adenocarcinoma

[Oncogene] Scientists found that the 18fluoro-deoxyglucose positron emission tomography/computed tomography-based markers were positively associated with the expression of programmed cell death ligand 1, pyruvate kinase M2, both of which indicate poor prognosis in patients with pancreatic ductal adenocarcinoma.

PDS Biotech Provides Recruitment update for National Cancer Institute-Led Phase 2 Clinical Trial of PDS0101-Based Combination

[PDS Biotechnology Corporation] PDS Biotechnology Corporation announced the reopening of recruitment in the National Cancer Institute-led Phase II clinical trial evaluating PDS0101 in combination with two investigational immune-modulating agents in advanced HPV cancers.

Cytokine-Induced Memory-Like Natural Killer Cells for Cancer Immunotherapy

[Stem Cell Research & Therapy] NK cells have always been thought to be short-lived and with no antigen specificity; however, recent data supports the presence of NK cell memory including in the hapten-specific contact hypersensitivity model and in certain viral infections.

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