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lymphocytes

Diversity of Human NK Cell Developmental Pathways Defined by Single-Cell Analyses

[Current Opinion in Immunology] Investigators offer a brief review of new insights into human NK cell diversity specifically defined by next generation sequencing and single-cell transcriptomic studies.

Single-Cell Transcriptomic Identified HIF1A as a Target for Attenuating Acute Rejection after Heart Transplantation

[Basic Research in Cardiology] A Total of 20 immune cell subtypes were identified among 46,040 cells. The function of immune cells in acute rejection were illustrated simultaneously.

Genetic Mapping Reveals Nfkbid as a Central Regulator of Humoral Immunity to Toxoplasma gondii

[PLoS Pathogens] The authors reported that unlike susceptible C57BL/6J mice, A/J mice were highly resistant to secondary infection.

Robust Immune Responses Are Observed after One Dose of BNT162b2 mRNA Vaccine Dose in SARS-CoV-2 Experienced Individuals

[Science Translational Medicine] Scientists evaluated longitudinal immune responses to two-dose BNT162b2 mRNA vaccination in 15 adults who had experienced COVID-19, compared to 21 adults who did not have prior COVID-19.

TNF Plays a Crucial Role in Inflammation by Signaling via T Cell TNFR2

[Proceedings of the National Academy of Sciences of the United States of America] Exposure of mouse CD4+ T cells to TNF and TGF-β generated Th17 cells that expressed low levels of IL-17 and high levels of inflammatory markers independently of IL-6 and STAT3.

Molecular Partners Announces Research Collaboration with University of Bern to Develop MP0533, a Multispecific DARPin for the Treatment of AML

[Molecular Partners AG] Molecular Partners AG announced a research collaboration with University of Bern, to advance the development of the company’s wholly owned acute myeloid leukemia candidate, MP0533, into the clinic.

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