Tag results:
lymphocytes
Immune Regulation News
The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity
[Cancer Immunology Research] An epigenetic CRISPR-Cas9 screen of 1,218 chromatin regulators identified TRIM28 as a suppressor of PD-L1 expression.
Immune Regulation News
Sequence and Vector Shapes Vaccine Induced Antibody Effector Functions in HIV Vaccine Trials
[PLoS Pathogens] Investigators compared vaccine responses in Phase I and II studies in humans utilizing various combinations of DNA/vector, vector/vector and DNA/protein HIV vaccines.
Hematopoiesis News
CD19-CAR T Cells Undergo Exhaustion DNA Methylation Programming in Patients with Acute Lymphoblastic Leukemia
[Cell Reports] To gain a deeper understanding of the molecular characteristics associated with CAR T cell differentiation, researchers performed longitudinal genome-wide DNA methylation profiling of CD8+ CD19-CAR T cells post-infusion in acute lymphoblastic leukemia patients.
Hematopoiesis News
Establishment of the TBX-Code Reveals Aberrantly Activated T-Box Gene TBX3 in Hodgkin Lymphoma
[PLoS One] Scientists revealed a lymphoid TBX-code and used it to identify an aberrant network around deregulated T-box gene TBX3 in Hodgkin lymphoma which promoted hallmark aberrations of this disease.
Hematopoiesis News
Acute Myeloid Leukemia Cell Membrane-Coated Nanoparticles for Cancer Vaccination Immunotherapy
[Leukemia] Researchers reported the development of an acute myeloid leukemia cell membrane-coated nanoparticle vaccine platform, in which immune-stimulatory adjuvant-loaded nanoparticles were coated with leukemic cell membrane material.
Hematopoiesis News
Phase Ib Study of the BET Protein Inhibitor RO6870810 with Venetoclax and Rituximab in Patients with Diffuse Large B Cell Lymphoma
[Blood Advances] Researchers reported results of a phase Ib dose-escalation study of the novel, subcutaneous BET inhibitor RO6870810 combined with the BCL-2 inhibitor venetoclax, and rituximab, in recurrent/refractory diffuse large B cell lymphoma.