lymphocytes

[Cell Reports] Researchers showed that the single-cell landscape of peripheral immune responses is reprogrammed in thrombocytopenia syndrome (SFTS) and characterized by monocyte shift to an intermediate type along with complement activation, perturbation of plasmablast composition, and highly exhausted T cells.

[Molecular Therapy-Oncolytics] A novel DNA vaccine containing dual antigens of fibrinogen-like protein 1 and carbonic anhydrase IX was developed and intramuscularly delivered by PLGA/PEI nanoparticles for renal cancer therapy.

[eLife] The authors characterized cell free DNA released from specific immune cell types in healthy individuals, cross sectionally and longitudinally.

[Molecular Therapy-Oncolytics] Investigators combinated an oncolytic adenovirus carrying Decorin with a CAR-T targeting carbonic anhydrase IX to perform the anti-tumor activity for renal cancer cells.

[ACS Nano] Investigators described a strategy that utilizes pretargeting and glycochemistry to bioengineer β cells in situ to induce β-cell-specific tolerance.

[Technology Networrks] The California Institute for Regenerative Medicine governing board approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.