lymphocytes

[Journal of Experimental Medicine] Scientists reported the high expression of acetyl-CoA carboxylase 1 in the pathogenic CD4+ T cell population in the lung and skin.

[Journal of Experimental Medicine] Using single-cell transcriptomics, researchers discovered a unique CD8 T cell blood/tumor-shared subpopulation in melanoma patients with high levels of oxidative phosphorylation (OXPHOS), the ectonucleotidases CD38 and CD39, and both exhaustion and cytotoxicity markers.

[Cell Reports] Researchers demonstrated that lymphoid-tissue-inducer-like ILC3s were enriched in the lung-draining lymph nodes of healthy mice and humans.

[Cancer Science] The authors investigated the anti-adult T cell leukemia/lymphoma effects of a novel oral HSP90 inhibitor TAS-116 and the mechanisms involved in ex vivo and in vivo preclinical models.

[Stem Cell Research & Therapy] Scientists genetically modified human iPSCs with a zinc finger nuclease technology to introduce a cDNA encoding an anti-EpCAM chimeric antigen receptor into the adeno-associated virus integration site 1, a “safe harbour” for transgene insertion into human genome.

[Blood] Scientists hypothesized that the mechanism responsible was IL-15/N-803 promoting recipient CD8 T cell activation that in turn accelerated donor NK cell rejection.