lymphocytes

[Trends in Cancer] The authors synthesize recent findings on T cell antigen receptor and CAR signaling and highlights the potential strategies of T cell engineering by signaling refinement.

[Immunity] Transcriptional profiling of intra-tumoral dendritic cells (DCs) within regressor tumors revealed an activation state of CD11b+ conventional DCs characterized by expression of interferon-stimulated genes.

[Cancer Immunology Research] Transcriptome analysis revealed that B7-H3 was highly expressed in PD-L1-low, non-immunoreactive high-grade serous ovarian cancer tumors, and its expression negatively correlated with an IFNγ signature, which reflected the tumor immune-reactivity.

[Immunity] Scientists found that skin CD4+ tissue-resident memory T cells were depleted after HIV infection and replenished only upon early antiretroviral therapy initiation.

[Journal For Immunotherapy of Cancer] Autologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for two weeks to generate the organoid-primed T cells.

[Cancer Research] Emerging evidence indicates B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. The authors generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.