lymphocytes

[Molecular Therapy-Methods & Clinical Development] Using a non-viral piggyBac transposon technology and human peripheral blood derived primary natural killer (NK) cells, scientists generated CAR-NK cells to target NKG2D ligands.

[Nature Communications] The authors developed third-generation anti-CD123 CAR T cells with a humanized CSL362-based ScFv and a CD28-OX40-CD3ζ intracellular signaling domain.

[Nature Communications] Investigators showed that the 4-1BB CSD-associated tonic signal yielded a more dramatic effect in CAR-Tregs than in CAR- conventional T cells with respect to activation and proliferation.

[Trends in Immunology] A spate of recent studies investigating tumor immune evasion through the application of CRISPR-based gene-editing screens have highlighted tumor necrosis factor (TNF)-mediated killing as an important component of the mammalian T cell antitumor repertoire.

[Current Opinion in Immunology] Data indicated that systemic and local chemo/radiotherapy regimens promoted intratumoral cytokine and chemokine upregulation, tumor antigen presentation and cross presentation, infiltration and in situ T cells reactivation.

[American Journal of Human Genetics] Researchers systematically applied Mendelian randomization, genetic colocalization, immune-cell-type enrichment, and phenome-wide association methods to investigate the effects of genetically predicted gene expression on ten immune-associated diseases and four cancer outcomes.