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lymphocytes

Landscape of Hopx Expression in Cells of the Immune System

[Heliyon] Scientists reported a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions.

B Cell-Derived GABA Elicits IL-10+ Macrophages to Limit Anti-Tumor Immunity

[Nature] The authors identified the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and secreted by activated B cells and plasma cells.

Multispecific Targeting of Glioblastoma with Tumor Microenvironment-Responsive Multifunctional Engineered NK Cells

[Proceedings of the National Academy of Sciences of the United States of America] Scientists described a unique, sophisticated combinatorial platform for glioblastoma (GMB): a cooperative multifunctional immunotherapy based on genetically engineered human NK cells bearing multiple antitumor functions including local tumor responsiveness that addresses key drivers of GBM resistance to therapy.

Endotoxin Contamination in Commercially Available Cas9 Proteins Potentially Induces T Cell Mediated Responses

[Gene Therapy] The authors addressed the issue of endotoxin levels in laboratory grade Cas9 proteins used to measure T cell memory responses.

Recruitment of Dendritic Cell Progenitors to Foci of Influenza A Virus Infection Sustains Immunity

[Science Immunology] The authors showed that effective induction of T cell responses against influenza A virus in mice requires reinforcement of the resident lung conventional dendritic cells (cDC) network by cDC progenitors.

Immunomodulation and RNA Interference Alter Hepatitis B Virus-Specific CD8 T Cell Recognition of Infected HepG2-NTCP

[Hepatology] Hepatitis B virus infected HepG2-NTCP were treated with tenofovir disoproxil fumarate, Toll-like receptor 7/8 agonists, TLR7/8 conditioned media collected from immune cells, or RNAi using short-interfering RNAs.

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