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lymphocytes

Activation of AMPKα1 Is Essential for Regulatory T Cell Function and Autoimmune Liver Disease Prevention

[Cellular & Molecular Immunology] Both transplantation of wild-type bone marrow and adoptive transfer of wild-type Treg cells could prevent liver injury in AMPKα1-KO mice.

Interleukin-2 and Regulatory T Cells in Rheumatic Diseases

[Nature Reviews Rheumatology] Restoration of Treg cell fitness and/or expansion of their numbers using low-dose natural IL-2, the main cytokine driving Treg cell survival and function, has demonstrated clinical efficacy in early clinical trials.

Modulation of Intrinsic Inhibitory Checkpoints Using Nano-Carriers to Unleash NK Cell Activity

[EMBO Molecular Medicine] Scientists described a non-viral lipid nanoparticle-based delivery system that encapsulated small interfering RNAs to gene silence the key intrinsic inhibitory NK cell molecules, SHP-1, Cbl-b, and c-Cbl.

How to Reliably Define Human CD8+ T Cell Subsets: Markers Playing Tricks

[Cold Spring Harbor Perspectives in Biology] Scientists summarize the understanding of the current state in the human CD8+ T cell subset characterization field.

BNT162b2 Vaccination Induces Durable SARS-CoV-2 Specific T Cells with a Stem Cell Memory Phenotype

[Science Immunology] Researchers monitored T cell responses to the Spike protein of SARS-CoV-2 in 71 healthy donors vaccinated with two doses of the Pfizer–BioNTech mRNA vaccine for up to six months after vaccination.

Mass Spectrometric Identification of Immunogenic SARS-CoV-2 Epitopes and Cognate TCRs

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that, in contrast to current convention, “immunodominant” SARS-CoV-2 peptides defined by in silico methods often failed to elicit T cell responses recognizing naturally presented SARS-CoV-2 epitopes.

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