lymphocytes

[Nature Immunology] Scientists characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. They showed that maternal SARS-CoV-2 infection affected the neonatal immune system.

[Surface Oncology] Surface Oncology, an immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, announced details about its plan to initiate a randomized Phase II clinical study evaluating SRF388, in combination with Roche’s atezolizumab and bevacizumab, in patients with treatment-naïve hepatocellular carcinoma.

[Science Advances] Researchers developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release.

[Nature Communications] The authors analyzed CD127+ innate lymphoid cells (ILCs) and natural killer cells in intestinal lamina propria from healthy donors and Crohn’s disease patients and identified two populations of CD127+CD94+ ILCs, designated population A and B, that could be distinguished on the expression of CD117, CD18 and cytotoxic molecules.

[US FDA] The US FDA approved brexucabtagene autoleucel for adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). Efficacy was evaluated in ZUMA-3, a single-arm multicenter trial that evaluated brexucabtagene autoleucel, a CD19-directed chimeric antigen receptor T-cell therapy, in adults with relapsed or refractory B-cell precursor ALL.

[Cancer Immunology Research] Scientists showed that Bacillus Calmette-Guérin (BCG) increased the number of tumor antigen-specific αβ T cells in patients with bladder cancer.