lymphocytes

[Cell] Investigators engineered CAR-T cells to deliver RN7SL1, an endogenous RNA that activates RIG-I/MDA5 signaling. RN7SL1 promoted expansion and effector-memory differentiation of CAR-T cells.

[UCLA Newsroom] Scientists Dr. Cristina Puig-Saus and Dr. Daniel Shin from the UCLA Jonsson Comprehensive Cancer Center have received a $1 million Translational Research Award from the US Department of Defense Melanoma Research Program to help advance the use of chimeric antigen receptor, or CAR, T cell therapy as a treatment for people with acral, mucosal and uveal melanomas.

[Scientific Reports] Researchers investigated arthritis development in male DBA/1 mice which were injected with bovine collagen II and human fibrinogen on days 0 and 21, leading to stable and reproducible disease induction in 100% of immunized mice.

[Cancer Immunology Research] Investigators engineered a Natural Killer cell line to express CD64, the sole human high-affinity IgG Fcγ receptor, and bound these cells with antibodies to provide interchangeable tumor-targeting elements.

[Cancer Immunology] To identify long-term changes in gene expression after irradiation, PC3 and LNCaP prostate cancer cells were irradiated with either a single dose or a fractionated regimen of 10 fractions.

[Prostate] The development of immunotherapy in cancer treatment has brought an exciting era of antiprostate cancer therapy through antitumor immune responses.