RNA-Seq Profiling of Microdissected Glomeruli Identifies Potential Biomarkers for Human IgA Nephropathy

Scientists collected glomeruli from biopsy specimens from immunoglobulin A nephropathy (IgAN) patients with relatively preserved kidney function and from normal kidney cortices by hand microdissection and performed RNA-seq.
[American Journal of Physiology-Renal Physiology]
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Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

Coculturing CD19-expressing β-like cells and CD19 CAR-T cells resulted in T cell-mediated β-like cell death with release of activated T cell cytokines.
[Cell Reports Medicine]
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CD122-Selective Il-2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade

Despite strong tumor rejection, IL-2c unexpectedly lowered the tumor microenvironmental CD8+/Treg ratio. IL-2c reduced tumor microenvironmental Treg suppression and induced a fragile Treg phenotype, helping explain improved efficacy despite numerically increased Tregs without affecting Treg in draining lymph nodes.
[Cancer Research]
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The Innate Immune Effector ISG12a Promotes Cancer Immunity by Suppressing the Canonical Wnt/β-Catenin Signaling Pathway

ISG12a was found to be expressed at low levels in gastrointestinal cancer, represented by hepatocellular cancer and gastric cancer, and identified as a tumor suppressor that affects clinical prognosis.
[Cellular & Molecular Immunology]
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Revisiting the PD-1 Pathway

The authors provide an overview of the recent advances on the mechanistic aspects of the PD-1 pathway and discuss the implications of these new discoveries and the gaps that remain to be filled.
[Science Advances]
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Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Scientists completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects.
[Cell]
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Inducible Secretion of IL-21 Augments Anti-Tumor Activity of piggyBac-Manufactured Chimeric Antigen Receptor T Cells

Scientists engineered CAR T cell to co-express IL-21 and studied the effects of IL-21 on CAR T cells specific to CD19 and prostate-specific membrane antigens using an in vitro co-culture model and NSG mice transplanted with B-cell tumors.
[Cytotherapy]
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New Insight Into the Role of Exosomes in Vitiligo

The authors investigate the association of exosomes with vitiligo and emphasize the role of exosomes in immune regulation, melanocyte–keratinocyte interactions, and melanogenesis.
[Autoimmunity Reviews]
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Autophagy Promotes Growth of Tumors with High Mutational Burden by Inhibiting a T-Cell Immune Response

Researchers showed that autophagy, especially in the liver, promotes tumor immune tolerance by enabling regulatory T-cell function and limiting stimulator of interferon genes, T-cell response and interferon-γ, which enables growth of high-tumor mutational burden tumors.
[Nature Cancer]
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Tmunity Announces First Patient Dosed in Phase I Clinical Trial with CART-TnMUC1

Tmunity Therapeutics, Inc. announced that it has dosed the first patient in its Phase I CART-TnMUC1-01 clinical trial with the Tn/STn glycoform of mucin 1 (TnMUC1) CAR-T therapy in patients with TnMUC1-positive advanced cancers.
[Tmunity Therapeutics, Inc.]
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Hepatocellular Carcinoma—The Influence of Immunoanatomy and the Role of Immunotherapy

Investigators summarize hepatocellulr carcinoma (HCC), its staging system, current therapy and immunotherapy medications currently being utilized or studied in the treatment of HCC with the hopes of highlighting what is being done and suggesting what needs to be done in the future to champion this therapy as an effective option.
[International Journal of Molecular Sciences]
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