lymphocytes

[Nature Communications] HLA-DQ8-HIP tetramer+ T cells from the peripheral blood of a T1D patient are characterized by repeated TRBV5 usage, which matched the TCR bias of CD4+ T cells reactive to the HIP peptide isolated from the pancreatic islets of a patient with T1D.

[Journal of Experimental Medicine] The authors screened related Löfgren’s syndrome-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 of Aspergillus nidulans that stimulated these CD4+ T cells in an HLA-DR3–restricted manner.

[Scientific Reports] The authors explored expression patterns and prognostic value of secretory carrier-associated membrane proteins (SCAMPs) and network analysis of SCAMPs-related signaling pathways in acute myeloid leukemia using Oncomine, GEPIA, cBioPortal, LinkedOmics, DAVID and Metascape databases.

[Cancer Immunology Research] Using a screening approach, the authors identified fibronectin as a functional ligand for immunoglobulin-like transcript 3 (ILT3). The interaction of fibronectin with ILT3 polarized myeloid cells toward a suppressive state, and these effects were reversed with an ILT3-specific antibody that blocked the interaction of ILT3 with fibronectin.

[Blood Advances] Patients with VEXAS syndrome had a propensity toward developing cytopenia, myelodysplastic syndrome, multiple myeloma, and venous thromboembolism. Bone marrow from patients with VEXAS showed characteristic vacuolization of myeloid and erythroid precursors.

[Stem Cell Research & Therapy] Scientists discuss and explain the most recent advances in chimeric antigen receptor (CAR) T cell-based therapies targeting acute myeloid leukemia (AML) antigens and review the results of preclinical and clinical trials.