lymphocytes

[Genome Biology] The authors showed that large deletions were ubiquitous but were dependent on editing sites and cell types. Human primary T cells displayed more significant deletions than hematopoietic stem and progenitor cells, whereas they observed low levels in induced pluripotent stem cells.

[Mucosal Immunology] Researchers indicated that intraepithelial CD8+ T cells were activated upon infection of intestinal epithelial cells with SARS-CoV-2, providing one possible explanation for gastrointestinal symptoms associated with COVID-19.

[Mucosal Immunology] Flow cytometric, ultrastructural and transcriptional profiling showed that αEβ7-expressing antibody-secreting cells represented an undescribed subset of terminally-differentiated intestinal plasma cells that established direct cell to cell contact with intestinal epithelium.

[Cell Reports] Researchers compared the immune profiles generated by KrasG12D-mutated mouse pancreatic ductal epithelial cells engineered genetically to express the Trp53R172H mutation with their p53 wild-type control.

[Cell Reports] Scientists reported that pro-inflammatory β cell small extracellular vesicles induced β cell dysfunction, promoted a pro-inflammatory islet transcriptome, and enhanced recruitment of CD8+ T cells and macrophages.

[Scientific Reports] Researchers established human and mouse hepatocellular carcinoma cells with exon 3 skipping of β-catenin, which promoted nuclear translocation and activated the Wnt/β-catenin signaling pathway, by using newly developed multiplex CRISPR/Cas9-based genome engineering system.