lymphocytes

[Nature Immunology] Using single-cell ATAC-sequencing and paired single-cell RNA and T cell receptor sequencing to map mouse adipose Treg cells, scientists identified CD73hiST2lo and CD73loST2hi subsets with distinct clonal expansion patterns.

[Science Signaling] To design CARs with a lower activation threshold, scientists compared antigen-induced pathway signaling in human T cells expressing a current CAR construct to that in cells with endogenous TCRs.

[Science Signaling] The authors examined how these diverse responses are orchestrated in human dendritic cells (DCs). Single-cell analyses revealed that the response to modified vaccinia virus Ankara infection in DCs was limited to early viral gene expression.

[Nature Communications] Investigators used an MHC Associated Peptide Proteomics assay to identify SaCas9 peptides presented by MHC Class II (MHC-II) proteins on dendritic cells.

[Journal of Clinical Investigation] Scientists demonstrated that ZFP91 perturbed T cell metabolic and functional states in the TME and suggested that targeting ZFP91 may improve the efficacy of cancer immunotherapy.

[Scientific Reports] The authors reported a phenotypic screening of a human secretome library in human Treg cells utilising a high throughput flow cytometry technology.