Enhanced SARS-CoV-2 Neutralization by Dimeric IgA

Scientists characterized the IgA response to SARS-CoV-2 in a cohort of 149 convalescent individuals after diagnosis with COVID-19. IgA responses in plasma generally correlated with IgG responses.
[Science Translational Medicine]
Wang, Z., Lorenzi, J. C. C., Muecksch, F., Finkin, S., Viant, C., Gaebler, C., Cipolla, M., Hoffman, H.-H., Oliveira, T. Y., Oren, D. A., Ramos, V., Nogueira, L., Michailidis, E., Robbiani, D. F., Gazumyan, A., Rice, C. M., Hatziioannou, T., Bieniasz, P. D., Caskey, M., & Nussenzweig, M. C. (2021). Enhanced SARS-CoV-2 neutralization by dimeric IgA. Science Translational Medicine, 13(577). https://doi.org/10.1126/scitranslmed.abf1555 Cite
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Discriminating Mild From Critical COVID-19 by Innate and Adaptive Immune Single-Cell Profiling of Bronchoalveolar Lavages

In mild COVID-19, CD8+ resident-memory and CD4+ T-helper-17 cells underwent active expansion towards the end of the trajectory, and were characterized by good effector functions, while in critical COVID-19 they remain more naïve.
[Cell Research]
Wauters, E., Van Mol, P., Garg, A. D., Jansen, S., Van Herck, Y., Vanderbeke, L., Bassez, A., Boeckx, B., Malengier-Devlies, B., Timmerman, A., Van Brussel, T., Van Buyten, T., Schepers, R., Heylen, E., Dauwe, D., Dooms, C., Gunst, J., Hermans, G., Meersseman, P., … Lambrechts, D. (2021). Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages. Cell Research, 1–19. https://doi.org/10.1038/s41422-020-00455-9 Cite
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HLA Class I Loss in Colorectal Cancer: Implications for Immune Escape and Immunotherapy

Investigators summarize the prevalence and molecular mechanisms behind HLA-I loss in colorectal cancer (CRC), and discuss HLA-I expression/loss in the context of the newly identified CRC molecular subtypes.
[Cellular & Molecular Immunology]
Anderson, P., Aptsiauri, N., Ruiz-Cabello, F., & Garrido, F. (2021). HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy. Cellular & Molecular Immunology, 1–10. https://doi.org/10.1038/s41423-021-00634-7 Cite
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Advances in the Development of Personalized Neoantigen-Based Therapeutic Cancer Vaccines

Scientists provide an overview of the complex process that is necessary to generate a personalized neoantigen vaccine, review the types of vaccine-induced T cells that are found within tumours and outline strategies to enhance the T cell responses.
[Nature Reviews Clinical Oncology]
Blass, E., & Ott, P. A. (2021). Advances in the development of personalized neoantigen-based therapeutic cancer vaccines. Nature Reviews Clinical Oncology, 1–15. https://doi.org/10.1038/s41571-020-00460-2 Cite
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Spatiotemporal Single-Cell Profiling Reveals That Invasive and Tissue-Resident Memory Donor CD8+ T Cells Drive Gastrointestinal Acute Graft-Versus-Host Disease

Scientists combined the serial intravascular staining technique with single-cell RNA sequencing to dissect the tightly connected processes by which donor T cells initially infiltrate tissues and then established a pathogenic tissue residency program in a rhesus macaque allo-HCT model that develops acute graft-versus-host disease.
[Science Translational Medicine]
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease | Science Translational Medicine. (n.d.). Retrieved January 22, 2021, from https://stm.sciencemag.org/content/13/576/eabc0227 Cite
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FYN–TRAF3IP2 Induces NF-κB Signaling-Driven Peripheral T-Cell Lymphoma

Consistent with a driver oncogenic role, FYN–TRAF3IP2 expression in hematopoietic progenitors induced NF-κB-driven T-cell transformation in mice and cooperated with loss of the Tet2 tumor suppressor in peripheral T-cell lymphoma development.
[Nature Cancer]
FYN – TRAF3IP2 induces NF-κB signaling-driven peripheral T-cell lymphoma | Nature Cancer. (n.d.). Retrieved January 22, 2021, from https://www.nature.com/articles/s43018-020-00161-w Cite
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Genomic Profiles and Tumor Immune Microenvironment of Primary Lung Carcinoma and Brain Oligo-Metastasis

Scientists recruited 33 lung cancer patients with brain oligo-metastasis to explore the genomic features and tumor immune microenvironment of the lung and brain metastasis independently.
[Cell Death & Disease]
Song, Z., Yang, L., Zhou, Z., Li, P., Wang, W., Cheng, G., Chen, R., Chang, L., Zhang, Y., Guan, Y., Xia, X., Yi, X., Zhou, R., & Chen, M. (2021). Genomic profiles and tumor immune microenvironment of primary lung carcinoma and brain oligo-metastasis. Cell Death & Disease, 12(1), 1–10. https://doi.org/10.1038/s41419-021-03410-7 Cite
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Modeling, Optimization, and Comparable Efficacy of T Cell and Hematopoietic Stem Cell Gene Editing for Treating Hyper‐IgM Syndrome

Investigators developed a one‐size‐fits‐all editing strategy for effective T‐cell correction, selection, and depletion and investigated the therapeutic potential of T‐cell and hematopoietic stem/progenitor cell therapies in the hyper‐IgM syndrome mouse model.
[EMBO Molecular Medicine]
Vavassori, V., Mercuri, E., Marcovecchio, G. E., Castiello, M. C., Schiroli, G., Albano, L., Margulies, C., Buquicchio, F., Fontana, E., Beretta, S., Merelli, I., Cappelleri, A., Rancoita, P. M., Lougaris, V., Plebani, A., Kanariou, M., Lankester, A., Ferrua, F., Scanziani, E., … Genovese, P. (2021). Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome. EMBO Molecular Medicine, n/a(n/a), e13545. https://doi.org/10.15252/emmm.202013545 Cite
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A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer

Investigators discuss the cellular phenotypes and spatial patterns of the lymphoid-, myeloid-, and stromal cells in the TNBC microenvironment and the potential value of mapping these features onto tumor cell genotypes.
[Cancers]
Nederlof, I., Horlings, H. M., Curtis, C., & Kok, M. (2021). A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer. Cancers, 13(2), 316. https://doi.org/10.3390/cancers13020316 Cite
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Lipophagy Confers a Key Metabolic Advantage That Ensures Protective CD8A T-Cell Responses against HIV-1

Scientists showed that, after both polyclonal and HIV-1-specific activation, CD8A T-cells from ART displayed reduced autophagy-dependent degradation of lysosomal contents when compared to naturally HIV-1 protected elite controllers.
[Autophagy]
Loucif, H., Dagenais-Lussier, X., Beji, C., Cassin, L., Jrade, H., Tellitchenko, R., Routy, J.-P., Olagnier, D., & Grevenynghe, J. van. (2021). Lipophagy confers a key metabolic advantage that ensures protective CD8A T-cell responses against HIV-1. Autophagy, 0(0), 1–16. https://doi.org/10.1080/15548627.2021.1874134 Cite
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Enoxacin Upregulates microRNA Biogenesis and Downregulates Cytotoxic CD8 T Cell Function in Autoimmune Cholangitis

Scientists showed that liver‐infiltrating dnTGFβRII CD8 T cells have significantly decreased levels of the miRNA biogenesis molecules P4ha1 and Ago2 along with significantly increased levels of granzyme B and perforin.
[Hepatology]
Itoh, A., Adams, D., Huang, W., Wu, Y., Kachapati, K., Bednar, K. J., Leung, P. S. C., Zhang, W., Flavell, R. A., Gershwin, M. E., & Ridgway, W. M. (n.d.). Enoxacin upregulates microRNA biogenesis and downregulates cytotoxic CD8 T cell function in autoimmune cholangitis. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31724 Cite
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