lymphocytes

[Science Translational Medicine] The authors found that anti–cytotoxic T lymphocyte–associated protein 4 (CTLA-4)×SIRPα preferentially depleted ICOShigh immunosuppressive Treg cells in the tumor microenvironment and enhanced immunity against solid tumors, including MC38 and CT26 murine colon cancers.

[Cancer Letters] The authors discuss perturbation of cell death in prostate cancer and how new therapeutics could improve treatment outcome in prostate cancer.

[Nature Immunology] The authors describe the history of research on bystander CD8+ T cell activation as well as evidence of bystander activation. They also discuss the mechanisms and immunopathological roles of bystander activation in various microbial infections.

[Nature Cancer] Scientists reported a Phase I–cleared orally bioavailable MTKI, ESK981, with a novel autophagy inhibitory property that decreased tumor growth in diverse preclinical models of castration-resistant prostate cancer.

[Nature Biomedical Engineering] Scientists show that human somatic cells can be directly reprogrammed into natural killer cells with a CD56brightCD16bright phenotype using pluripotency transcription factors and an optimized reprogramming medium.

[Nature Communications] The authors demonstrated that mice lacking the hypoxia-inducible factor-1α isoform in natural killer (NK) cells showed impaired release of the cytokines Interferon (IFN)-γ and granulocyte macrophage - colony stimulating factor as part of a blunted immune response.