lymphocytes

[Science Immunology] Investigators reported that caspase-8 was a central regulator of regulatory T cell homeostasis in a context-specific manner that was decisive during immune responses.

[Cell Metabolism] Scientists showed that glycolytic reprogramming additionally controlled inflammatory gene expression via epigenetic remodeling. They found that the glucose transporter GLUT3 was essential for the effector functions of Th17 cells in models of autoimmune colitis and encephalomyelitis.

[Molecular Carcinogenesis] Scientists hypothesized that TGF-β receptor inhibition may alter Pancreatic ductal adenocarcinoma progression and antitumor immunity in the tumor microenvironment.

[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists discuss the advancement of PCSK9 research on its role and underlying mechanisms in tumor development and progression.

[Cell Death Discovery] In functional in vitro experiments, researchers observed that calmodulin-binding transcription activator 1 (Camta1) overexpression significantly decreased the proliferation and invasion capacity of SW620 and SW480 cells.

[Immunity] Researchers used single-cell ECCITE-seq, which captures surface protein expression, cellular transcriptome, HIV-1 RNA, and TCR sequences within the same single cell to track clonal expansion dynamics in longitudinally archived samples from six HIV-1-infected individuals and two uninfected individuals.