Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells

Investigators simultaneously assayed single-cell heteroplasmy and cell state in thousands of blood cells obtained from three unrelated patients who had A3243G-associated mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes.
[New England Journal of Medicine]
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Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells

Scientists found in vivo activation of NK cells during Listeria monocytogenes infection augmented transcription of genes encoding mitochondria-associated proteins in a manner dependent upon the transcriptional coactivator PGC-1α.
[iScience]
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Clearance of HIV Infection by Selective Elimination of Host Cells Capable of Producing HIV

Scientists showed an approach to eradicate HIV infections by selective elimination of host cells harboring replication-competent HIV, which included viral reactivation, induction of cell death, inhibition of autophagy and the blocking of new infections.
[Nature Communications]
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A Novel Approach to Genetic Engineering of T-Cell Subsets by Hematopoietic Stem Cell Infection with a Bicistronic Lentivirus

Two T-cell specific promoters were assessed: the distal Lck—and the CD3δ-promoter. Transduced hematopoietic stem cells were FACS sorted by mCherry expression and transferred into sublethally irradiated C57/BL6 mice.
[Scientific Reports]
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COVID-19 Severity Associates with Pulmonary Redistribution of CD1c+ DC and Inflammatory Transitional and Nonclassical Monocytes

Investigators studied the frequencies and activation profiles of dendritic cells and monocytes present in the blood and lung of COVID-19 patients with different clinical severity in comparison with healthy individuals.
[Journal of Clinical Investigation]
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Cytovia Therapeutics Licenses Productivity-Boosting Manufacturing Technology for Its NK Engager Multifunctional Antibodies From ProteoNic

Cytovia Therapeutics, Inc. has announced today that it has licensed from ProteoNic BV its 2G UNic™ technology for boosting recombinant protein production, allowing for cost-effective manufacturing at large scale. Under the agreement, Cytovia gains non-exclusive, worldwide commercial rights for application of the technology to the development of a number of its proprietary NK Engager multifunctional antibodies.
[Cytovia Therapeutics (GlobeNewswire Inc.)]
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Allogeneic Stem Cell Transplantation for Patients with Aggressive NK-Cell Leukemia

Using the Japanese transplant registry data, the outcomes of 59 aggressive NK-cell leukemia patients who underwent first allogeneic hematopoietic stem cell transplantation were analyzed. Twenty-nine patients received stem cells from cord blood, 18 from peripheral blood, and 12 from bone marrow.
[Bone Marrow Transplantation]
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Progress of Gene Therapy in Cardiovascular Disease

Researchers discuss the recent advances in proangiogenic gene therapy for critical limb ischemia and DNA vaccine for hypertension.
[Hypertension]
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Kinetically Distinct Processing Pathways Diversify the CD8+ T Cell Response to a Single Viral Epitope

Investigators determined that optimal CD8+ T cell expansion and function were induced by the peptides that were rapidly produced from the exceedingly minor fraction of protein mislocalized to the cytosol.
[Proceedings of the National Academy of Sciences of the United States of America]
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IL-9-Producing T Cells: Potential Players in Allergy and Cancer

The authors review the latest literature on the development of IL-9-producing T cells and their functions in disease settings, with a particular focus on allergy and cancer.
[Nature Reviews Immunology]
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cDC1 Prime and Are Licensed by CD4+ T Cells to Induce Anti-Tumour Immunity

Early priming of CD4+ T cells against tumor-derived antigens required cDC1, and this was not simply because they transport antigens to lymph nodes for processing by cDC2, as selective deletion of major histocompatibility class II molecules in cDC1 also prevented early CD4+ T cell priming.
[Nature]
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