lymphocytes

[Journal of Parkinsons Disease] Previous studies have shown that T cells play a key role both in the central nervous system and in the periphery, leading to a profound imbalance in the immune network of Parkinson's Disease patients.

[PLoS Pathogens] Researchers showed that the transcriptional co-activator and the central mediator of canonical Wnt signaling, β-catenin, inhibited HIV transcription in CD4+ T cells via TCF-4 LTR binding sites.

[Scientific Reports] Scientists investigated whether the EZH2 noncanonical pathway could be involved in early T cell maturation, which required cell polarization.

[Immunity] Researchers generated an epigenetic and transcriptional atlas of T cell differentiation from healthy humans that included exhausted CD8 T cells and applied this resource in three ways.

[Harpoon Therapeutics, Inc.] Harpoon Therapeutics, Inc. announced that the US FDA has granted Fast Track designation to HPN217, a BCMA-targeting TriTAC®, for the treatment of patients with relapsed, refractory multiple myeloma who have received at least four lines of therapy.

[Cancer Immunology Research] Researchers tested the in vitro effect of different natural killer (NK)-cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and targeted either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.