lymphocytes

[Immunity] Researchers investigated the relative contribution of potential ligands, stable peptide-MHC class II complexes and fibrinogen-like protein 1, to lymphocyte activation gene-3 (LAG-3) activity in vitro and in vivo.

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.

[Nature Communications] Scientists performed comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers.

[NPJ Vaccines] Researchers generated a virus-like particle (VLP) vaccine bearing the hemagglutinin of H1N1 A/California/07/09 that was unable to bind to its α(2,6)-linked sialic acid receptor and compared its immunogenicity and efficacy to a wild-type H1-VLP in mice.

[Nature Medicine] Investigators administered a recombinant bicistronic adeno-associated virus (AAV8) vector coding for both the light and heavy chains of the potent broadly neutralizing HIV-1 antibody VRC07 to eight adults living with HIV.

[Cell Reports] Investigators showed that HIV-1 cell-to-cell spread permited efficient, productive infection of resting memory T cells without prior activation.