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lymphocytes

Celyad Oncology Announces Voluntary Pause of CYAD-101-002 Phase Ib Trial

[Celyad Oncology] Celyad Oncology SA announced it has taken the decision to voluntarily pause the CYAD-101-002 Phase Ib trial due to reports of two fatalities that presented with similar pulmonary findings.

Tertiary Lymphoid Structures Generate and Propagate Anti-Tumor Antibody-Producing Plasma Cells in Renal Cell Cancer

[Immunity] Researchers used spatial transcriptomics to examine the nature of B cell responses within tertiary lymphoid structures in renal cell carcinoma.

TET2 Inactivation Restrains IL-10-Producing Regulatory B Cells to Enable Anti-Tumor Immunity in Hepatocellular Carcinoma

[Hepatology] TET2 activation in B cells triggered by oxidative stress from the hepatocellular carcinoma (HCC) microenvironment promoted IL-10 expression, while the adoptive transfer of Tet2-deficient B cells suppressed HCC progression.

Single-Cell Profiling of Human CD127+ Innate Lymphoid Cells Reveals Diverse Immune Phenotypes in Hepatocellular Carcinoma

[Hepatology] Investigators applied selection strategies to enrich innate lymphoid cells (ILC) populations in hepatocellular carcinoma (HCC) samples to investigate the effects of B cells on the immune reaction of ICOS+ ILC2 cells.

Metabolic Programs Tailor T Cell Immunity in Viral Infection, Cancer, and Aging

[Cell Metabolism] Researchers summarize recent advances of how metabolic circuits combined with epigenetic changes dictate T cell fate decisions and shape their functional states.

Rapid Synchronous Type 1 IFN and Virus-Specific T Cell Responses Characterize First Wave Non-severe SARS-CoV-2 Infections

[Cell Reports Medicine] The authors used blood transcriptomics, multiparameter flow cytometry, and T cell receptor sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses.

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