lymphocytes

[Molecular Therapy-Oncolytics] To improve CAR-T therapy for glioblastoma, a new TanCAR, comprising the tandem arrangement of IL13 and EphA2 scFv, was generated and validated in vitro and in vivo.

[Molecular Therapy-Oncolytics] The authors reported a new strategy of blocking the CD7 antigen on the T cell surface with a recombinant anti-CD7 antibody to obtain a sufficient amount of CD7-targeting CAR-T cells for T cell acute lymphoblastic leukemia treatment.

[Nature Biomedical Engineering] Scientists showed that functional CAR T cells could be generated within 24 hours from T cells derived from peripheral blood without the need for T cell activation or ex vivo expansion.

[Healio] The FDA granted orphan drug designation to CYNK-101, an investigational natural killer cell-based therapy for treatment of advanced HER2/neu-positive gastric or gastroesophageal junction adenocarcinoma.

[Cell Reports Medicine] The authors analyzed whole-exome and bulk RNA sequencing of tumors from new and published cohorts of 189 and 178 patients with melanoma receiving checkpoint blockade, respectively.

[Molecular Cell] Researchers identified FBXO7 as a maintenance regulator of mesenchymal and immune evasion phenotypes of cancer cells.