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lymphocytes

Spatial, Temporal and Molecular Dynamics of Swine Influenza Virus-Specific CD8 Tissue Resident Memory T Cells

[Mucosal Immunology] Most nucleoprotein-specific CD8 T cells in broncho-alveolar lavage and lung are tissue resident memory cells that express CD69 and downregulate CD45RA and CCR7.

PDS Biotech Announces Clinical Trial with Mayo Clinic to Study PDS0101 in Early Stage Pre-Metastatic- HPV-Associated Head and Neck Cancer

[PDS Biotechnology Corporation] PDS Biotechnology Corporation announced the initiation of an Investigator-Initiated Trial, MC200710, for PDS0101 alone or in combination with the checkpoint inhibitor, KEYTRUDA®, in patients with HPV-associated oropharyngeal cancer at high risk of recurrence.

Intellia and ONK Therapeutics Announce Collaboration to Advance Allogeneic CRISPR-Edited NK Cell Therapies for the Treatment of Patients with Cancer

[Intellia Therapeutics, Inc.] Intellia Therapeutics, Inc., a company focused on developing curative therapies leveraging CRISPR-based technologies, and ONK Therapeutics Ltd., a company dedicated to developing optimally engineered NK cell therapies to treat cancer, announced a licensing and collaboration agreement.

Mesenchymal Stem Cells Transfer Mitochondria to Allogeneic Tregs in an HLA-Dependent Manner Improving Their Immunosuppressive Activity

[Nature Communications] Researchers demonstrated how direct and indirect contact with allogenic MSCs improves regulatory T cells' (Tregs) potential for accumulation of immunosuppressive adenosine and suppression of conventional T cell proliferation, making them more potent therapeutic tools.

Human Umbilical Cord Mesenchymal Stem Cells Alleviate the Imbalance of CD4+ T Cells via Protein Tyrosine Phosphatase Non-Receptor Type 2/Signal Transducer and Activator of...

[Endocrine Journal] Researchers investigated the therapeutic effect of human umbilical cord MSCs on experimental autoimmune thyroiditis (EAT) and the underlying mechanisms by utilizing a porcine thyroglobulin-induced EAT rat model.

Defined Tumor Antigen-Specific T Cells Potentiate Personalized TCR-T Cell Therapy and Prediction of Immunotherapy Response

[Cell Research] T cells engineered with T cell receptors (TCRs) from naturally occurring tumor antigen-specific T cells in a patient will target personal tumor-specific antigens in their tumor.

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