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lymphocytes

Legend Biotech Achieves Milestone Payments in BCMA CAR-T Collaboration with Janssen

[Legend Biotech Corporation] Legend Biotech Corporation achieved two milestones under its collaboration agreement with Janssen Biotech, Inc. for ciltacabtagene autoleucel, a B cell maturation antigen-directed CAR-T therapy.

Multipurposing CARs: Same Engine, Different Vehicles

[Molecular Therapy] Researchers are now studying how to expand CAR T s technology beyond its use in conventional polyclonal αβ T cells to address limitations to the current therapy in cancer and applications beyond it.

Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors Treatment

[Frontiers in Immunology] The authors provide an overview of the major mechanisms used by tumor cells to evade immune defenses and they critically expose the most optimistic engineering strategies to make CAR-T cell therapy a solid option for solid tumors.

A New kCa3.1 Channel Activator SKA-346 Boosts T Cell Antitumor Response in the Immune Suppressive Microenvironment

[Biophysical Journal] The authors demonstrated that T cells exposed to high-e dose-dependently accumulated [K+]e intracellularly.

Tryptophan-Derived Microbial Metabolites Activate the Aryl Hydrocarbon Receptor in Tumor-Associated Macrophages to Suppress Anti-Tumor Immunity

[Immunity] Researchers examined the impact of aryl hydrocarbon receptor in tumor-associated macrophage function in pancreatic ductal adenocarcinoma.

Differential Virus-Specific IFN-Gamma Producing T Cell Responses to Marek’s Disease Virus in Chickens with B19 and B21 MHC Haplotypes

[Frontiers in Immunology] The frequencies of IFN-gamma producing pp38 and MEQ-specific T cell responses were determined in line N and line P2a chickens after infection with vaccine and/or virulent strains of Marek’s disease virus using both standard ex vivo and cultured chIFN-gamma ELISPOT assays.

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