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lymphocytes

The Anthelmintic Drug Niclosamide Induces GSK-β-Mediated β-Catenin Degradation to Potentiate Gemcitabine Activity, Reduce Immune Evasion Ability and Suppress Pancreatic Cancer Progression

[Cell Death & Disease] Niclosamide inhibited proliferation of pancreatic cancer cells, induced apoptosis via the mitochondrial-mediated pathway, and suppressed cell migration and invasion by antagonizing epithelial-to-mesenchymal transition.

Decade-Long Leukemia Remissions with Persistence of CD4+ CAR T Cells

[Nature] CAR T cells remained detectable more than ten years after infusion, with sustained remission in both patients.

CD38 Knockout Natural Killer Cells Expressing an Affinity Optimized CD38 Chimeric Antigen Receptor Successfully Target Acute Myeloid Leukemia with Reduced Effector Cell Fratricide

[Haematologica] Researchers developed a CD38 CAR-NK cell therapy for acute myeloid leukemia, first by using an NK cell line which had low baseline CD38 expression and subsequently NK cells expanded from healthy donors.

Cytosolic dsRNA Improves Neonatal Innate Immune Responses to Adjuvants in Use in Pediatric Vaccines

[Journal of Leukocyte Biology] Researchers showed that myeloid cells from cord blood could be activated to express T cell costimulatory markers, and also to produced Th1 promoting cytokines.

Infection or a Third Dose of mRNA Vaccine Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Kidney Transplant Recipients

[Science Translational Medicine] Investigators observed that previous infection with SARS-CoV-2, but not the standard two-dose regimen of vaccination, provided protection against symptomatic COVID-19 in kidney transplant recipients.

CD97 Is Associated with Mitogenic Pathway Activation, Metabolic Reprogramming, and Immune Microenvironment Changes in Glioblastoma

[Scientific Reports] Using in silico and in vitro techniques, investigators demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma.

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