lymphocytes

[Journal of Virology] Scientists assessed the antiviral efficacy of HIV-specific iPSC-cytotoxic T lymphocytes by single- and multiple-round viral suppression assays.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists developed a clinically translatable approach for labeling CAR T cells with iron oxide nanoparticles, which enabled the noninvasive detection of the iron-labeled T cells with magnetic resonance imaging, photoacoustic imaging, and magnetic particle imaging.

[Cell Discovery] In non-human primates, CoVac501 elicited high and persistent titers of protective neutralizing antibodies against multiple receptor-binding domain mutations, SARS-CoV-2 original strain, and variants.

[American Journal of Pathology] Poorly formed necrotic tuberculosis (TB) granulomas containing a high expression of Mycobacterium tuberculosis antigens were elevated in TB/HIV co-infected lymph nodes, and inducible nitric oxide synthase as well as Arg-1 expression was significantly higher in TB/HIV co-infected compared to HIV-negative TB or control tissues.

[Journal of Virology] Researchers showed that the combined expression of Nef and Vpu predicted the susceptibility of HIV-1-infected primary CD4+ T cells to antibody-dependent cellular cytotoxicity by HIV+ plasma.

[eLife] Scientists used high-throughput sequencing of memory CD4 TCRβ repertoire and machine learning to showed that individuals with preexisting vaccine-reactive memory CD4 T cell clonotypes elicited earlier and higher antibody titers and mounted a more robust CD4 T cell response to hepatitis B vaccine.