lymphocytes

[Science Immunology] Researchers identified and characterize skin-resident T cells in humans defined by their long-term in situ lodgment.

[Cancer Gene Therapy] Cyclin-dependent kinase 12 (CDK12) activated MYC to repress miR-28-5p/EZH2 and amplified tonic BCR signaling to promote the development of diffuse large B cell lymphoma (DLBCL), which might provide potential therapeutic targets for future therapeutic intervention in DLBCL.

[Blood Cancer Journal] An RT-MPLA assay was applied to a consecutive series of 522 adult and pediatric T cell acute lymphoblastic leukemias and identified a fusion transcript in 20% of cases.

[Blood Cancer Journal] Since hypomethylating agents possessed immunomodulatory functions that constituted part of their anti-tumor effect, the authors set out to analyze the bone marrow immune environment by next-generation sequencing of T cell receptor beta repertoires in 51 AML patients treated within the RAS-AZIC trial.

[Nature Cancer] Scientists performed a systematic high-throughput combination drug screen and identified a synergistic interaction between the MEK inhibitor trametinib and the multi-kinase inhibitor nintedanib, which targeted KRAS-directed oncogenic signaling in mesenchymal PDAC.

[Molecular Therapy-Oncolytics] The authors provide an overview of current and on-going chimeric antigen receptor (CAR) T cell clinical studies in pancreatic cancer and the major challenges and strategies to improve CAR T cell efficacy.