lymphocytes

[Cancer Cell] Researchers proposed that lactic acid in the highly glycolytic tumor microenvironment (TME) was an active checkpoint for the function of regulatory T cells in the TME via upregulation of PD-1 expression.

[iScience] Scientists generated a doxycycline inducible MHC-I and II antigen expressing HCC cell line which allowed them to investigate tumor antigen specific T cell response in two non-alcoholic fatty liver disease (NAFLD) mouse models.

[Cell Reports Medicine] The authors demonstrated the feasibility of infusing multiple doses of ex vivo activated and expanded autologous NK cells in patients with multiple myeloma post-autologous stem cell transplantation.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated a method to skew CAR transduction toward naive T cells without physical cell sorting.

[Nature Communications] To target GRP78, scientists generated T cell expressing a GRP78-specific peptide-based CAR, which showed evidence of minimal fratricide post activation/transduction and antigen-dependent T cell differentiation.

[Nature Immunology] Scientists found that CCR6+ type 3 innate lymphoid cells could trigger an increase in the number of T cells infiltrating a tumor.