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lymphocytes

US FDA Approves New Label Update for CAR T-Cell Therapy Yescarta® Showing Prophylactic Steriod Use Improves Management of Cytokine Release Syndrome

[Kite] Kite announced the FDA approved an update to the prescribing information for Yescarta® to include use of prophylactic corticosteroids across all approved indications.

ICAM-1-Mediated Adhesion Is a Prerequisite for Exosome-Induced T Cell Suppression

[Developmental Cell] Scientists reported that the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) co-localized with programmed death ligand 1 (PD-L1) on the exosomes; both ICAM-1 and PD-L1 were upregulated by interferon-γ.

Modulating Oxidative Stress in B Cells Promotes Immunotherapy in Food Allergy

[Oxidative Medicine and Cellular Longevity] Researchers investigated the role of flagellin in promoting immunotherapy efficacy through modulating oxidative stress in regulatory B cells.

Adaptive Immune Cell Responses as Therapeutic Targets in Antibody-Mediated Organ Rejection

[Trends in Molecular Medicine] The authors discuss how recent investigations have uncovered the key contributions of T follicular helper and B cells and their coordinated actions in driving donor-specific antibody generation and immune progression towards antibody-mediated rejection.

TIM-3 Shuttled by MV3 Cells-Secreted Exosomes Inhibits CD4+ T Cell Immune Function and Induces Macrophage M2 Polarization to Promote the Growth and Metastasis of...

[Translational Oncology] Silencing of TIM-3 shuttled by MV3 cells-derived exosomes improved CD4+ T cell immune function and inhibited macrophage M2 polarization to attenuate the growth and metastasis of melanoma cells.

Management of Metastatic Melanoma with New Immunotherapy Approaches beyond PD-1/CTLA-4 Inhibitors

[Current Opinion in Oncology] Scientists focus on new immunotherapeutic approaches studied in advanced melanoma previously treated by anti-programmed cell death 1 (PD-1) receptor or anti-cytolytic T-lymphocyte-associated protein 4 (CTLA-4) antibodies.

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