Tag results:
lymphocytes
Cell Therapy News
Identification of Shared Tumor Epitopes from Endogenous Retroviruses Inducing High-Avidity Cytotoxic T Cells for Cancer Immunotherapy
[Science Advances] Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.
Human Immunology News
Multi-Objective Optimization Reveals Time- and Dose-Dependent Inflammatory Cytokine-Mediated Regulation of Human Stem Cell Derived T Cell Development
[NPJ Regenerative Medicine] Using a defined engineered thymic niche system, investigators undertook a multi-stage statistical learning-based optimization campaign and identified IL-3 and tumor necrosis factor α as a stage- and dose-specific enhancers of cell proliferation and T-lineage differentiation.
Cancer Stem Cell News
Lyell Immunopharma Announces FDA Clearance of IND for LYL132, a T-cell Receptor Therapy for Solid Tumors Being Developed in Collaboration with GSK
[Lyell Immunopharma, Inc. (Globenewswire, Inc.)] Lyell Immunopharma, Inc. announced that US FDA has cleared an Investigational New Drug (IND) application to initiate a Phase I clinical trial for LYL132, an investigational T-cell receptor therapy for patients with solid tumors expressing New York esophageal squamous cell carcinoma 1 that the company is developing in collaboration with GSK.
Human Immunology News
Exploiting Natural Killer Cell Engagers to Control Pediatric B Cell Precursor Acute Lymphoblastic Leukemia
[Cancer Immunology Research] Investigators tested the in vitro effect of different NK cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and target either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.
Immune Regulation News
Defective Humoral Immunity Disrupts Bile Acid Homeostasis Which Promotes Inflammatory Disease of the Small Bowel
[Nature Communications] Investigators used a CD19−/− mouse model of antibody-deficiency to demonstrate that a relationship exists between dysbiosis, defects in bile acid homeostasis, and gluten-sensitive enteropathy of the small intestine.
Human Immunology News
Polymorphonuclear Myeloid-Derived Suppressor Cells Are Abundant in Peripheral Blood of Cancer Patients and Suppress Natural Killer Cell Anti-Tumor Activity
[Frontiers in Immunology] Scientists showed that polymorphonuclear-myeloid-derived suppressor cells were present in high numbers in the polymorphonuclear of patients with primary or metastatic lung tumor.