Tag results:
lymphocytes
Immune Regulation News
Control of Tumors by Antigen-Specific CD8+ T Cells through PDL1-Targeted Delivery of Antigenic Peptide
[Journal of Immunology Research] Scientists generated a therapeutic chimeric protein containing the PD-L1 single-chain variable fragment linked to a cleavable model cytotoxic T lymphocyte epitope: E7 CTL peptide.
Human Immunology News
HLA-Independent T Cell Receptors for Targeting Tumors with Low Antigen Density
[Nature Medicine] The authors edited the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor–CD3 complex reconfigured to utilize the same immunoglobulin heavy and light chains as a matched CAR.
Immune Regulation News
Cytosporone B (Csn-B), an NR4A1 Agonist, Attenuates Acute Cardiac Allograft Rejection by Inducing Differential Apoptosis of CD4+ T Cells
[International Immunopharmacology] Researchers revealed that nuclear receptor subfamily 4 Group A member 1 was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+ T cells.
Immune Regulation News
EBV+ Tumors Exploit Tumor Cell-Intrinsic and -Extrinsic Mechanisms to Produce Regulatory T Cell-Recruiting Chemokines CCL17 and CCL22
[PLoS Pathogens] Both in vitro and in vivo Treg migration was effectively blocked by a novel, small molecule antagonist of CCR4, CCR4-351.
Immune Regulation News
Loss of CMTM6 Promotes DNA Damage-Induced Cellular Senescence and Antitumor Immunity
[Oncoimmunology] Investigators showed that chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) was upregulated in clear cell renal cell carcinoma tissues and was strongly associated with advanced tumor grades, early metastases, and a worse prognosis.
Immune Regulation News
Topical Astilbin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions in SKH-1 Mice via Suppression Dendritic Cell-Th17 Inflammation Axis
[Journal of Cellular and Molecular Medicine] Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.