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lymphocytes

Control of Tumors by Antigen-Specific CD8+ T Cells through PDL1-Targeted Delivery of Antigenic Peptide

[Journal of Immunology Research] Scientists generated a therapeutic chimeric protein containing the PD-L1 single-chain variable fragment linked to a cleavable model cytotoxic T lymphocyte epitope: E7 CTL peptide.

HLA-Independent T Cell Receptors for Targeting Tumors with Low Antigen Density

[Nature Medicine] The authors edited the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor–CD3 complex reconfigured to utilize the same immunoglobulin heavy and light chains as a matched CAR.

Cytosporone B (Csn-B), an NR4A1 Agonist, Attenuates Acute Cardiac Allograft Rejection by Inducing Differential Apoptosis of CD4+ T Cells

[International Immunopharmacology] Researchers revealed that nuclear receptor subfamily 4 Group A member 1 was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+ T cells.

EBV+ Tumors Exploit Tumor Cell-Intrinsic and -Extrinsic Mechanisms to Produce Regulatory T Cell-Recruiting Chemokines CCL17 and CCL22

[PLoS Pathogens] Both in vitro and in vivo Treg migration was effectively blocked by a novel, small molecule antagonist of CCR4, CCR4-351.

Loss of CMTM6 Promotes DNA Damage-Induced Cellular Senescence and Antitumor Immunity

[Oncoimmunology] Investigators showed that chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) was upregulated in clear cell renal cell carcinoma tissues and was strongly associated with advanced tumor grades, early metastases, and a worse prognosis.

Topical Astilbin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions in SKH-1 Mice via Suppression Dendritic Cell-Th17 Inflammation Axis

[Journal of Cellular and Molecular Medicine] Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.

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