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lymphocytes

KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGF-β Activity

[Molecular Cancer Research] Using MCF10A as a model of non-tumorigenic epithelial breast cells, scientists found that silencing KDM6A promoted cell migration and transformation demonstrated by the formation of tumor-like acini in three-dimensional culture.

Knockdown of Zinc Finger Protein 267 Suppresses Diffuse Large B-cell Lymphoma Progression, Metastasis, and Cancer Stem Cell Properties

[Bioengineered] Scientist found ZNF267 was significantly upregulated in diffuse large B-cell lymphoma and predicted a poor survival outcome based on the bioinformatics analysis.

Comparison of Single and Repeated Dosing of Anti-inflammatory Human Umbilical Cord Mesenchymal Stromal Cells in a Mouse Model of Polymicrobial Sepsis

[Stem Cell Reviews and Reports] Scientists investigated immunomodulatory effects of a novel mesenchymal stem cell product in mouse endotoxemia and polymicrobial sepsis models.

B Cells Imprint Adoptively Transferred CD8+ T Cells with Enhanced Tumor Immunity

[Journal For Immunotherapy of Cancer] Researchers investigated how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes were impacted when expanded ex vivo with the TLR9 agonist CpG.

CD4 and CD8 Co-Receptors Modulate Functional Avidity of CD1b-Restricted T Cells

[Nature Communications] Scientists showed CD1b-mycolipid tetramers revealed a hierarchy in which circulating T cells expressing CD4 or CD8 co-receptor stain with a higher tetramer mean fluorescence intensity than CD4-CD8- T cells.

Fate Therapeutics Announces FDA Clearance for FT536, a First-in-Class MICA/B-targeted CAR NK Cell Product Candidate for the Treatment of Solid Tumors

[Fate Therapeutics, Inc.] Fate Therapeutics, Inc. announced that the US FDA has cleared the company’s Investigational New Drug application for FT536, an off-the-shelf, multiplexed-engineered, iPSC-derived, chimeric antigen receptor NK cell product candidate.

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