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lymphoid cells

Early-Life Imprinting of Unconventional T Cells and Tissue Homeostasis

[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.

Intravenous Calcitriol Administration Modulates Mesenteric Lymph Node CD4+ T-cell Polarization and Attenuates Intestinal Inflammation in Obese Mice Complicated with Polymicrobial Sepsis

[Journal of Parenteral and Enteral Nutrition] Researchers investigated treatment with calcitriol on mesenteric lymph node CD4+ T cell polarization and intestinal injury in obese mice with sepsis.

Spatial Determinates of Effector and Memory CD8+ T Cell Fates

[Immunological Reviews] The authors detail the inflammatory and chemokine regulators of spatially restricted T cell differentiation, with a focus on how to promote stem-like memory cell.

Clinical Characterization and Immunosuppressive Regulation of CD161 (KLRB1) in Glioma through 916 Samples

[Cancer Science] Retrospective RNA-seq data analysis was conducted in a cohort of 313 patients with glioma in the Chinese Glioma Genome Atlas database and 603 patients in the TCGA database.

The Safety and Efficacy of CAR-T Cells in the Treatment of Prostate Cancer: Review

[Biomarkers] A new breakthrough development in cancer treatment is chimeric antigen receptor (CAR)-T cell therapy. The authors focus on its efficacy & safety in prostate cancer, obstacles impeding its clinical use, and some strategies trying to overcome them.

Homogeneous Antibody and CAR-T Cells with Improved Effector Functions Targeting SSEA-4 Glycan on Pancreatic Cancer

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that SSEA-4 was more expressed in all pancreatic cancer cell lines examined but not detectable in normal pancreatic cells.

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