Metabolic Conditioning of CD8+ Effector T Cells for Adoptive Cell Therapy

Investigators showed that transient glucose restriction in activated CD8+ effector T cells metabolically primed effector functions and enhanced tumor clearance in mice.
[Nature Metabolism]
Klein Geltink, R. I., Edwards-Hicks, J., Apostolova, P., O’Sullivan, D., Sanin, D. E., Patterson, A. E., Puleston, D. J., Ligthart, N. A. M., Buescher, J. M., Grzes, K. M., Kabat, A. M., Stanczak, M., Curtis, J. D., Hässler, F., Uhl, F. M., Fabri, M., Zeiser, R., Pearce, E. J., & Pearce, E. L. (2020). Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy. Nature Metabolism, 1–14. https://doi.org/10.1038/s42255-020-0256-z Cite
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Correlative Study of Epigenetic Regulation of Tumor Microenvironment in Spindle Cell Melanomas and Cutaneous Malignant Peripheral Nerve Sheath Tumors

Scientists investigated the epigenetic regulation of promoters and gene bodies and their effect on the tumor microenvironment composition of cutaneous malignant peripheral nerve sheath tumors and spindle cell melanomas.
[Scientific Reports]
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The Impact of Donor Type on the Outcome of Pediatric Patients with Very High Risk Acute Lymphoblastic Leukemia. A Study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG

Investigators demonstrated the impact of donor type on overall results of allogeneic stem cell transplantation for very-high risk pediatric acute lymphoblastic leukemia with worse results when using mismatched donor stem cell source.
[Bone Marrow Transplantation]
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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Targeting melanosomal proteins or oncogenic CDK4R24C by adoptive cell transfer of the same epitope-specific CD8+ T cells revealed diverse genetic and non-genetic immune escape mechanisms.
[Immunity]
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Overexpression of miR-382 Sensitizes Hepatocellular Carcinoma Cells to γδ T Cells through Inhibiting the Expression of C-Flip

As miR-382 was observed to be downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, researchers found that overexpression of miR-382 increased the sensitivity of HCC cells to γδ T cells.
[Molecular Therapy-Oncolytics]
Chen, Z., Zheng, Z., Feng, L., Huo, Z., Huang, L., Fu, M., Chen, Q., Ke, Y., Yang, J., & Hou, B. (2020). Overexpression of miR-382 sensitizes hepatocellular carcinoma cells to γδ T cells through inhibiting the expression of c-FLIP. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.07.012 Cite
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Induced Pluripotent Stem Cell-Derived Natural Killer Cells Gene-Modified to Express Chimeric Antigen Receptor-Targeting Solid Tumors

Scientists describe the characteristics of natural killer (NK) cells from multiple cell sources, including PSCs, the chimeric antigen receptor (CAR)-modification method and strategy for these NK cells.
[International Journal of Hematology]
Ueda, T., & Kaneko, S. (2020). Induced pluripotent stem cell-derived natural killer cells gene-modified to express chimeric antigen receptor-targeting solid tumors. International Journal of Hematology. https://doi.org/10.1007/s12185-020-02951-5 Cite
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Comparative Study between Human Mesenchymal Stem Cells and Etanercept as Immunomodulatory Agents in Rat Model of Rheumatoid Arthritis

Adipose tissue mesenchymal stem cells were able to delay the onset of collagen-induced arthritis, suppress the ongoing clinical and histopathological signs, decrease serum levels of TNF-α and anti-collagen type II, and downregulate the autoreactive T cells as etanercept.
[Immunologic Research]
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Regulatory T Cells Are Less Sensitive to Glucocorticoid Hormone Induced Apoptosis than CD4+ T Cells

Investigators analyzed the apoptosis-inducing effect of high dose in vitro dexamethasone treatment in mouse thymic- and splenic Tregs and CD4+ T cells.
[Apoptosis]
Prenek, L., Litvai, T., Balázs, N., Kugyelka, R., Boldizsár, F., Najbauer, J., Németh, P., & Berki, T. (2020). Regulatory T cells are less sensitive to glucocorticoid hormone induced apoptosis than CD4+ T cells. Apoptosis. https://doi.org/10.1007/s10495-020-01629-x Cite
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Engineering CAR-T Cells for Next-Generation Cancer Therapy

Investigators highlight recent strategies to improve chimeric antigen therapy (CAR)-T cell therapy by engineering the CAR protein, T cells, and the interaction between T cells and other components in the tumor microenvironment.
[Cancer Cell]
Hong, M., Clubb, J. D., & Chen, Y. Y. (2020). Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.07.005 Cite
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Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models

Researchers generated and characterized traceable CAR T cells and examined potential negative effects of radionuclide reporter use. They applied the platform to two different triple-negative breast cancer models and unexpectedly observed pronounced differences in CAR-T tumor retention by PET/computed tomography and confirmed data ex vivo.
[Molecular Therapy]
Volpe, A., Lang, C., Lim, L., Man, F., Kurtys, E., Ashmore-Harris, C., Johnson, P., Skourti, E., Rosales, R. T. M. de, & Fruhwirth, G. O. (2020). Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.06.028 Cite
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Regulatory T Cells Suppress Th17 Cell Ca2+ Signaling in the Spinal Cord during Murine Autoimmune Neuroinflammation

Investigators used two-photon microscopy to elucidate the spatial organization, motility characteristics, and interactions of endogenous Treg and Th17 cells together with antigen-presenting cells within the spinal cord leptomeninges in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
[Proceedings of the National Academy of Sciences of the United States of America]
Othy, S., Jairaman, A., Dynes, J. L., Dong, T. X., Tune, C., Yeromin, A. V., Zavala, A., Akunwafo, C., Chen, F., Parker, I., & Cahalan, M. D. (2020). Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006895117 Cite
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