Tag results:
lymphoid cells
Intestinal Cell News
SIRT1 Induces the Accumulation of TAMs at Colorectal Cancer Tumor Sites via the CXCR4/CXCL12 Axis
[Cellular Immunology] Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.
Immune Regulation News
Peripheral Tolerance by Treg via Constraining OX40 Signal in Autoreactive T Cells against Desmoglein 3, a Target Antigen in Pemphigus
[Proceedings of the National Academy of Sciences of the United States of America] Scientists used desmoglein 3, a pemphigus antigen expressed in keratinocytes, to analyze peripheral tolerance under physiological antigen-expression conditions.
Immune Regulation News
The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity
[Cancer Immunology Research] An epigenetic CRISPR-Cas9 screen of 1,218 chromatin regulators identified TRIM28 as a suppressor of PD-L1 expression.
Immune Regulation News
Sequence and Vector Shapes Vaccine Induced Antibody Effector Functions in HIV Vaccine Trials
[PLoS Pathogens] Investigators compared vaccine responses in Phase I and II studies in humans utilizing various combinations of DNA/vector, vector/vector and DNA/protein HIV vaccines.
Hematopoiesis News
CD19-CAR T Cells Undergo Exhaustion DNA Methylation Programming in Patients with Acute Lymphoblastic Leukemia
[Cell Reports] To gain a deeper understanding of the molecular characteristics associated with CAR T cell differentiation, researchers performed longitudinal genome-wide DNA methylation profiling of CD8+ CD19-CAR T cells post-infusion in acute lymphoblastic leukemia patients.
Hematopoiesis News
Establishment of the TBX-Code Reveals Aberrantly Activated T-Box Gene TBX3 in Hodgkin Lymphoma
[PLoS One] Scientists revealed a lymphoid TBX-code and used it to identify an aberrant network around deregulated T-box gene TBX3 in Hodgkin lymphoma which promoted hallmark aberrations of this disease.