lymphoid cells

[Life Sciences] Scientists inhibited two of the most important immune checkpoints expressed on T cells infiltrated in tumors, including PD-1 and A2aR. Ligation of PD-1 with PD-L1 and A2aR with adenosine significantly suppress T cell responses against tumor cells.

[BMC Medicine] The effect of combined SFN and CAR-T cells was determined in vitro using a co-culture system and in vivo using a xenograft mouse model. They furthered validated the effects of combination therapy in patients with cancer.

[Nature Reviews Immunology] Scientists discuss novel latency-reversing agents targeting DCs as well as DC-based strategies to enhance the clearance of infected cells by CD8+ T cells and strategies to improve the killing activity of natural killer cells.

[Frontiers in Immunology] The authors explored the combination between zeste homolog 2 (EZH2) inhibitor and an agonist antibody targeting the T cell costimulatory receptor 4-1BB.

[Journal of Immunology] Through the engineering of an HLA-DR1 chimeric Ag receptor (CAR), the authors produced CD8+ CAR T cells that target CD4+ T cells in an Ag-specific manner and tested their ability to inhibit the development of autoimmune arthritis in a mouse model.

[Todos Medical, Ltd.] Todos Medical, Ltd. announced that it has entered into an exclusive European licensing & distribution agreement with T Cell Protect Hellas S.A. for a product based on its Tollovid® and Tollovid Daily™ 3CL protease inhibitor and immune support dietary supplements.