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lymphoid cells

Features of Repertoire Diversity and Gene Expression in Human Cytotoxic T Cells Following Allogeneic Hematopoietic Cell Transplantation

[Communications Biology] Scientists showed the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T cells in actual recipients according to the cytomegalovirus reactivation pattern.

Therapeutic Melanoma Inhibition by Local Micelle-Mediated Cyclic Nucleotide Repression

[Nature Communications] Researchers demonstrated that single-cell sequencing of melanoma-infiltrating immune cells showed that adenylate cyclase inhibitor micelles reduced the number of anti-inflammatory myeloid cells and checkpoint receptor expression on T cells.

The Unique Symptom Burden of Patients Receiving CAR T-Cell Therapy

[Seminars in Oncology] Patients who received standard CAR T cell therapy experienced numerous symptoms related to disease and CAR T cell therapy, including symptoms related to the T cell infusion.

Allogeneic Stem Cell Transplantation in Patients with Mantle Cell Lymphoma: Results from the MANTLE-FIRST Study on Behalf of Fondazione Italiana Linfomi

[Leukemia & Lymphoma] Investigators retrospectively analyzed 55 patients who underwent allogeneic stem cell transplantation for mantle cell lymphoma relapsed or refractory after rituximab and high-dose cytarabine within the MANTLE-FIRST project.

Oncogenic Role of SOX9-DHCR24-Cholesterol Biosynthesis Axis in IGH-BCL2 Positive Diffuse Large B Cell Lymphomas

[Blood] Silencing of SOX9 decreased cell proliferation, induced G1/S arrest and increased apoptosis of diffuse large B-cell lymphoma cells, both in vitro and in vivo.

Homeostatic Cytokines Tune Naivety and Stemness of Cord Blood-Derived Transgenic T Cells

[Cancer Gene Therapy] Investigators proposed an optimized process using cord blood to generate minimally differentiated T-cell products in terms of phenotype, function, gene expression, and metabolism, using peripheral blood-derived T cells cultured with IL-2 as a standard.

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