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lymphoid cells

A Fructosylated Peptide Derived from a Collagen II T Cell Epitope for Long-Term Treatment of Arthritis (FIA-CIA) in Mice

[Scientific Reports] Researchers investigated arthritis development in male DBA/1 mice which were injected with bovine collagen II and human fibrinogen on days 0 and 21, leading to stable and reproducible disease induction in 100% of immunized mice.

Simultaneous Engagement of Tumor and Stroma Targeting Antibodies by Engineered NK-92 Cells Expressing CD64 Controls Prostate Cancer Growth

[Cancer Immunology Research] Investigators engineered a Natural Killer cell line to express CD64, the sole human high-affinity IgG Fcγ receptor, and bound these cells with antibodies to provide interchangeable tumor-targeting elements.

Long-Term Expression Changes of Immune-Related Genes in Prostate Cancer after Radiotherapy

[Cancer Immunology] To identify long-term changes in gene expression after irradiation, PC3 and LNCaP prostate cancer cells were irradiated with either a single dose or a fractionated regimen of 10 fractions.

Immunotherapy in Treatment of Metastatic Prostate Cancer: An Approach to Circumvent Immunosuppressive Tumor Microenvironment

[Prostate] The development of immunotherapy in cancer treatment has brought an exciting era of antiprostate cancer therapy through antitumor immune responses.

Antibody Secreting Cells Are Critically Dependent on Integrin α4β7/MAdCAM-1 for Intestinal Recruitment and Control of the Microbiota during Chronic Colitis

[Mucosal Immunology] β7 deficiency and MAdCAM-1 blockade specifically depleted antibody secreting cells from the colonic LP, leading to a fecal pan-immunoglobulin deficit, severe colitis, and alterations of microbiota composition.

An In Vivo Selection-Derived D-Peptide for Engineering Erythrocyte-Binding Antigens That Promote Immune Tolerance

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated a straightforward approach based on erythrocyte binding to promote antigen-specific tolerance to both peptides and proteins, and showed that a fully D-chiral peptide library could be selected in vivo for the de novo discovery of a robust erythrocyte binder, which they attached to peptide and protein antigens.

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