A Single-Domain Bispecific Antibody Targeting CD1d and the NKT T-Cell Receptor Induces a Potent Antitumor Response

Researchers describe how single-domain antibodies (VHH), specific for the human major histocompatibility complex class I-like molecule CD1d, could modulate the function of CD1d-restricted T cells and how one VHH specifically induced strong type I natural killer T (NKT) cell activation.
[Nature Cancer]
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Atypical Immune Phenotype in Severe Combined Immunodeficiency Patients with Novel Mutations in IL2RG and JAK3

Researchers report clinical course, immunological, genetic and proteomic work-up of two patients with different novel mutations in the IL-2-Janus kinase 3 (JAK3) pathway with a rare atypical presentation of TB+NK severe combined immunodeficiency.
[Genes & Immunity]
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In Vivo Detection of Antigen-Specific CD8+ T Cells by Immuno-Positron Emission Tomography

SynTacs, when labeled with positron-emitting isotopes, could noninvasively image antigen-specific CD8+ T cells in vivo.
[Nature Methods]
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Meningeal γδ T Cells Regulate Anxiety-Like Behavior via IL-17a Signaling in Neurons

Through a cellular and molecular characterization of meningeal γδ17 T cells, the authors defined the nearest central nervous system–associated source of IL-17a under homeostasis.
[Nature Immunology]
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A Regulatory T Cell Notch4–GDF15 Axis Licenses Tissue Inflammation in Asthma

Researchers found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T cells was necessary for allergens and particulate matter pollutants to promote airway inflammation.
[Nature Immunology]
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Long-Term MALT1 Inhibition in Adult Mice without Severe Systemic Autoimmunity

Scientists showed that long-term MALT1 inactivation, starting in adulthood, was not associated with severe systemic inflammation, despite reduced regulatory T cells.
[iScience]
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The Neurotransmitter Receptor Gabbr1 Regulates Proliferation and Function of Hematopoietic Stem and Progenitor Cells

Analysis revealed that hematopoietic stem/progenitor cell numbers were significantly reduced in the bone marrow compared to wild-type littermates. Moreover, g-aminobutyric acid type B receptor subunit 1 null hematopoietic stem cells had diminished capacity to reconstitute irradiated recipients in a competitive transplantation model.
[Blood]
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Crosstalk Between Hedgehog Pathway and the Glucocorticoid Receptor Pathway as a Basis for Combination Therapy in T-Cell Acute Lymphoblastic Leukemia

Researchers presented a therapeutically relevant crosstalk between Hedgehog (HH) signaling and the glucocorticoid receptor pathway acting at the level of GLI1 transcription factor.
[Oncogene]
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Combination of Anti-Angiogenic Therapy and Immune Checkpoint Blockade Normalizes Vascular-Immune Crosstalk to Potentiate Cancer Immunity

Combining anti-angiogenic therapy and immune checkpoint inhibitors is a valid therapeutic strategy that can enhance cancer immunity and will further expand the landscape of cancer treatment.
[Experimental and Molecular Medicine]
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Absent B Cells, Agammaglobulinemia, and Hypertrophic Cardiomyopathy in Folliculin Interacting Protein 1 Deficiency

The authors investigated three novel patients, including the first known adult, from unrelated families with agammaglobulinemia, recurrent infections, and hypertrophic cardiomyopathy.
[Blood]
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Retinoic Acid-Responsive CD8 Effector T-cells Are Selectively Increased in IL-23-Rich Tissue in Gastrointestinal GvHD

Investigators used conventional and novel sequential immunostaining and flow cytometry to scrutinize RA-responsive T-cells in tissues and blood of allogeneic hematopoietic stem-cell transplantation patients and characterized the impact of RA on human T-cell alloresponses.
[Blood]
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