Researchers describe how single-domain antibodies (VHH), specific for the human major histocompatibility complex class I-like molecule CD1d, could modulate the function of CD1d-restricted T cells and how one VHH specifically induced strong type I natural killer T (NKT) cell activation.
[zotpress userid=’1254621′ items=’D6ILKIXK’ style=’apa’ cite=’yes’]
Researchers report clinical course, immunological, genetic and proteomic work-up of two patients with different novel mutations in the IL-2-Janus kinase 3 (JAK3) pathway with a rare atypical presentation of T−B+NK− severe combined immunodeficiency.
[Genes & Immunity]
[zotpress userid=’1254621′ items=’PHR2WFA4′ style=’apa’ cite=’yes’]
SynTacs, when labeled with positron-emitting isotopes, could noninvasively image antigen-specific CD8+ T cells in vivo.
[zotpress userid=’1254621′ items=’Y4LM8RDR’ style=’apa’ cite=’yes’]
Through a cellular and molecular characterization of meningeal γδ17 T cells, the authors defined the nearest central nervous system–associated source of IL-17a under homeostasis.
[zotpress userid=’1254621′ items=’LC22RLAS’ style=’apa’ cite=’yes’]
Researchers found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T cells was necessary for allergens and particulate matter pollutants to promote airway inflammation.
[zotpress userid=’1254621′ items=’8HTCBZTT’ style=’apa’ cite=’yes’]
Scientists showed that long-term MALT1 inactivation, starting in adulthood, was not associated with severe systemic inflammation, despite reduced regulatory T cells.
[zotpress userid=’1254621′ items=’RW8YF3EF’ style=’apa’ cite=’yes’]
Analysis revealed that hematopoietic stem/progenitor cell numbers were significantly reduced in the bone marrow compared to wild-type littermates. Moreover, g-aminobutyric acid type B receptor subunit 1 null hematopoietic stem cells had diminished capacity to reconstitute irradiated recipients in a competitive transplantation model.
[zotpress userid=’1254621′ items=’V9WYNWC2′ style=’apa’ cite=’yes’]
Researchers presented a therapeutically relevant crosstalk between Hedgehog (HH) signaling and the glucocorticoid receptor pathway acting at the level of GLI1 transcription factor.
[zotpress userid=’6807162′ items=’TAI2DKPP’ style=’apa’ cite=’yes’]
Combining anti-angiogenic therapy and immune checkpoint inhibitors is a valid therapeutic strategy that can enhance cancer immunity and will further expand the landscape of cancer treatment.
[Experimental and Molecular Medicine]
[zotpress userid=’6445212′ items=’SFYLZRL8′ style=’apa’ cite=’yes’]
The authors investigated three novel patients, including the first known adult, from unrelated families with agammaglobulinemia, recurrent infections, and hypertrophic cardiomyopathy.
Investigators used conventional and novel sequential immunostaining and flow cytometry to scrutinize RA-responsive T-cells in tissues and blood of allogeneic hematopoietic stem-cell transplantation patients and characterized the impact of RA on human T-cell alloresponses.