lymphoid cells

[Mucosal Immunology] Flow cytometric, ultrastructural and transcriptional profiling showed that αEβ7-expressing antibody-secreting cells represented an undescribed subset of terminally-differentiated intestinal plasma cells that established direct cell to cell contact with intestinal epithelium.

[Cell Reports] Researchers compared the immune profiles generated by KrasG12D-mutated mouse pancreatic ductal epithelial cells engineered genetically to express the Trp53R172H mutation with their p53 wild-type control.

[Cell Reports] Scientists reported that pro-inflammatory β cell small extracellular vesicles induced β cell dysfunction, promoted a pro-inflammatory islet transcriptome, and enhanced recruitment of CD8+ T cells and macrophages.

[Scientific Reports] Researchers established human and mouse hepatocellular carcinoma cells with exon 3 skipping of β-catenin, which promoted nuclear translocation and activated the Wnt/β-catenin signaling pathway, by using newly developed multiplex CRISPR/Cas9-based genome engineering system.

[Nature Immunology] Using single-cell ATAC-sequencing and paired single-cell RNA and T cell receptor sequencing to map mouse adipose Treg cells, scientists identified CD73hiST2lo and CD73loST2hi subsets with distinct clonal expansion patterns.

[Science Signaling] To design CARs with a lower activation threshold, scientists compared antigen-induced pathway signaling in human T cells expressing a current CAR construct to that in cells with endogenous TCRs.