lymphoid cells

[Science Signaling] The authors examined how these diverse responses are orchestrated in human dendritic cells (DCs). Single-cell analyses revealed that the response to modified vaccinia virus Ankara infection in DCs was limited to early viral gene expression.

[Nature Communications] Investigators used an MHC Associated Peptide Proteomics assay to identify SaCas9 peptides presented by MHC Class II (MHC-II) proteins on dendritic cells.

[Journal of Clinical Investigation] Scientists demonstrated that ZFP91 perturbed T cell metabolic and functional states in the TME and suggested that targeting ZFP91 may improve the efficacy of cancer immunotherapy.

[Scientific Reports] The authors reported a phenotypic screening of a human secretome library in human Treg cells utilising a high throughput flow cytometry technology.

[Journal of Clinical Investigation] Scientists found that CD4+ Tfh TIL, CD8+ TIL and TIL-B, co-localizing in TLS, all expressed the CXCL13 receptor CXCR5.

[Molecular Oncology] Researchers explored the translation control of melanoma-overexpressed antigen 1 (MELOE-1) and provided evidence that heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) bound to the MELOE-1 internal ribosomal entry sequence (IRES) and acted as an IRES trans-activating factor to promote the translation of MELOE-1 in melanoma cells.