lymphoid cells

[Cell] The authors identified a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors.

[Molecular Therapy-Methods & Clinical Development] Investigators showed that these self-amplifying mRNA SARS-CoV-2 vaccines raised potent neutralizing antibody responses in mice against not only the original virus but also the alpha, beta, gamma, and delta variants.

[Science Immunology] Investigators reported that caspase-8 was a central regulator of regulatory T cell homeostasis in a context-specific manner that was decisive during immune responses.

[Cell Metabolism] Scientists showed that glycolytic reprogramming additionally controlled inflammatory gene expression via epigenetic remodeling. They found that the glucose transporter GLUT3 was essential for the effector functions of Th17 cells in models of autoimmune colitis and encephalomyelitis.

[Molecular Carcinogenesis] Scientists hypothesized that TGF-β receptor inhibition may alter Pancreatic ductal adenocarcinoma progression and antitumor immunity in the tumor microenvironment.

[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists discuss the advancement of PCSK9 research on its role and underlying mechanisms in tumor development and progression.