lymphoid cells

[Stroke] Lymphocytes from Nur77GFP transgenic mice express a fluorescent protein upon activation via the TCR, allowing the differentiation of activation mode in a natural repertoire of immune cells and antigens.

[Trends in Immunology] Investigators summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.

[Science] Given the well-established role of CD4 T cells in sustaining germinal centers (GCs) and the emerging role of Foxp3 in suppressing this reaction, scientists sought to determine whether expression of Foxp3 by GC-resident T cells could also play a role in GC longevity.

[Leukemia] In this open-label, single-arm Phase I/II trial, 87 patients with recurrent/refractory non-Hodgkin lymphoma received an infusion at doses of 0.5 × 106–8 × 106 TanCAR7 T cells per kilogram of body weight after conditioning chemotherapy.

[British Journal of Haematology] Researchers reported the development of carHLH in 14·8% of paediatric patients and young adults treated with CD19-specific CAR T-cell therapy with carHLH, occurring most commonly in those with high disease burden.

[Cell Metabolism] Researchers exploited the power of a visceral adipose tissue (VAT)-Treg TCR-transgenic mouse model to follow the dynamics of, and phenotypic changes in, the VAT-Treg population throughout the development of diet-induced obesity.