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lymphoid cells

Interferon-Armed RBD Dimer Enhances the Immunogenicity of RBD for Sterilizing Immunity against SARS-CoV-2

[Cell Research] To enhance antigen processing and cross-presentation in draining lymph nodes, scientists developed an interferon-armed receptor-binding domain dimerized by an immunoglobulin fragment.

Probiotic Supplementation Reduces Inflammatory Profiles but Does Not Prevent Oral Immune Perturbations during SIV Infection

[Scientific Reports] Researchers revealed that similar to the GI mucosae, oral CD4+ T cells were rapidly depleted, and as one of the first comprehensive analyses of the oral microflora in SIV infection, they also observed significant modulation among two genera, Porphyromonas and Actinobacillus, early after infection.

Combining CD47 Blockade with Trastuzumab Eliminates HER2-Positive Breast Cancer Cells and Overcomes Trastuzumab Tolerance

[Proceedings of the National Academy of Sciences of the United States of America] Researchers leveraged human epidermal-growth-factor receptor-2 (HER2) overexpression to engage antibody-dependent cellular phagocytosis through a combination of trastuzumab and anti-CD47 macrophage checkpoint immunotherapy.

Immune Responses against SARS-CoV-2 Variants after Heterologous and Homologous ChAdOx1 nCoV-19/BNT162b2 Vaccination

[Nature Medicine] Researchers used Hannover Medical School’s COVID-19 Contact Study cohort of healthcare professionals to monitor ChAdOx1-nCov-19 (ChAd)-primed immune responses before and three weeks after booster with ChAd or BioNTech/Pfizer’s BNT162b2.

ImmunityBio Announces Authorization to Proceed with Phase I/II/III Randomized Trial in South Africa of Their Dual-Antigen T-Cell Vaccine as a Universal Boost in Previously...

[ImmunityBio, Inc.] ImmunityBio, Inc. announced authorization from the South Africa Health Products Regulatory Authority to proceed with the South Africa Sisonke T-Cell Universal Boost trial. The Phase I/II/III study, which will begin in Q3 2021, is designed to evaluate hAd5 Spike + Nucleocapsid as a boost for South African healthcare workers previously vaccinated with an S-only vaccine.

Immune Cell Analyses of the Tumor Microenvironment in Prostate Cancer Highlight Infiltrating Regulatory T Cells and Macrophages as Adverse Prognostic Factors

[Journal of Pathology] The authors characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in the prostate tumor microenvironment.

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