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lymphoid cells

BTN2A1, an Immune Checkpoint Targeting Vγ9Vδ2 T Cell Cytotoxicity against Malignant Cells

[Cell Reports] Scientists showed that butyrophilin 2A1 (BTN2A1) was required for BTN3A-mediated Vγ9Vδ2 T cell cytotoxicity against cancer cells, and that expression of the BTN2A1/BTN3A1 complex was sufficient to trigger Vγ9Vδ2 TCR activation.

Mechanistic Basis for Chromosomal Translocations at the E2A Gene and Its Broader Relevance to Human B Cell Malignancies

[Cell Reports] Researchers demonstrated the ssDNA state in the 23 bp E2A fragile zone using several methods, including native bisulfite DNA structural analysis in live human pre-B cells.

Macrophage and Neutrophil Death Programs Differentially Confer Resistance to Tuberculosis

[Immunity] Researchers defined crucial in vivo functions of the death receptor-mediated and BCL-2-regulated apoptosis pathways in mediating protection against tuberculosis by eliminating distinct populations of infected macrophages and neutrophils and priming T cell responses.

CD27−CD38+ B Cells Accumulated in Early HIV Infection Exhibit Transitional Profile and Promote HIV Disease Progression

[Cell Reports] While investigating B cell subsets among individuals recently infected with HIV, the authors observe an accumulation of CD27−CD38+ B cells and find that these cells can directly facilitate HIV infection of primary CD4+ T cells in vitro.

Neutrophil-Derived Reactive Oxygen Species Promote Tumor Colonization

[Communications Biology] The authors observed fewer tumor foci in Ncf1 mutant mice, irrespective of αβT, γδT, B-cell deficiencies, or of a functional Ncf1 expression in CD68-positive monocytes/macrophages.

HLA-DR Cancer Cells Expression Correlates with T Cell Infiltration and Is Enriched in Lung Adenocarcinoma with Indolent Behavior

[Scientific Reports] Scientists identified cellular subpopulations of epithelial cancer cells and their microenvironment and validated their results by multiplex immunofluorescence applied to a tissue microarray of long and short-predicted survival lung adenocarcinoma.

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