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lymphoid cells

Phase III Randomized Trial of Chemotherapy with or without Oblimersen in Older AML Patients: CALGB 10201 (Alliance)

[Blood Advances] Untreated older acute myeloid leukemia (AML) patients were randomized to cytarabine and daunorubicin followed by cytarabine consolidation with or without G3139. Addition of G3139 to chemotherapy failed to improve outcomes of older AML patients.

CytoDyn’s Trial for Metastatic Triple-Negative Breast Cancer Demonstrates Safety with 350 mg, 525 mg and 700 mg Dosages; Officially Advances to Phase II from...

[CytoDyn, Inc.] CytoDyn, Inc., a biotechnology company developing leronlimab, a CCR5 antagonist, announced its clinical trial with leronlimab in combination with carboplatin for the treatment of metastatic TNBC has advanced from Phase Ib to a Phase II trial.

Locoregional Infusion of HER2-Specific CAR T Cells in Children and Young Adults with Recurrent or Refractory CNS Tumors: An Interim Analysis

[Nature Medicine] Researchers showed that engineering of a medium-length CAR spacer enhances the therapeutic efficacy of human erb-b2 receptor tyrosine kinase 2 (HER2)-specific CAR T cells in an orthotopic xenograft medulloblastoma model.

The Post-transplant Scoring System (PTSS) Is Associated with Outcomes in Patients with MDS after CD34+selected Allogeneic Stem Cell Transplant

[Bone Marrow Transplantation] The authors investigated the prognostic value of the PTSS in a cohort of patients with MDS who underwent myeloablative CD34-selected TCD transplants.

Effects of Fatty Acids on T Cell Function: Role in Atherosclerosis

[Nature Reviews Cardiology] Investigators discuss the effects of fatty acids on four components of the T cell response - metabolism, activation, proliferation and polarization - and the influence of these changes on the pathogenesis of atherosclerosis.

Interplay between Interleukin-6 Signaling and the Vascular Endothelium in Cytokine Storms

[Experimental & Molecular Medicine] Scientists highlight the distinct contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and discuss potential therapeutic strategies for the management of cytokine storms, including those associated with sepsis and COVID-19.

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