lymphoid cells

[Cell Death Discovery] In functional in vitro experiments, researchers observed that calmodulin-binding transcription activator 1 (Camta1) overexpression significantly decreased the proliferation and invasion capacity of SW620 and SW480 cells.

[Immunity] Researchers used single-cell ECCITE-seq, which captures surface protein expression, cellular transcriptome, HIV-1 RNA, and TCR sequences within the same single cell to track clonal expansion dynamics in longitudinally archived samples from six HIV-1-infected individuals and two uninfected individuals.

[Science Translational Medicine] The authors presented a microbial-based immunotherapeutic treatment for selective delivery of an immunogenic tetanus toxoid protein into pancreatic ductal adenocarcinom tumor cells by attenuated Listeria monocytogenes.

[Nature Communications] By investigating the resistance mechanisms, scientists found that MCL1 and JUNB modulated the mitochondrial apoptosis pathway. JUNB encoded a transcription factor that downregulates FasL and TRAIL receptors, upregulated the MCL1 relative BCL2A1, and activated the NF-κB pathway.

[Neurobiology of Disease] Current evidence points towards infiltrating monocytes as also playing a role in neuron death. Further characterization of the successive molecular changes in both the resident and peripheral immune cells invading the Parkinson's disease brain will provide targets for disease modification.

[International Immunology] The authors summarize the advances in our understanding of the ability of different types of TLRs and their downstream signaling pathways to activate anti-tumor immunity in T cells.