lymphoid cells

[Science Advances] Using a reverse translational approach, investigators showed a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8–dependent mechanism.

[BMC Cancer] Researchers observed tumor formation in NOD SCID mice after a single subcutaneous injection of human umbilical cord-MSCs and the effect of these cells on tumor growth in tumor-bearing mice.

[Molecular Cancer] The authors evaluate several of the ongoing and future directions of combining next-generation CRISPR-Cas9 gene editing with synthetic biology to optimize CAR T-cell therapy for future clinical trials toward the establishment of a new cancer treatment paradigm.

[Blood] The authors reported the first German real-world data on standard-of-care CAR-T cell therapies with the aim to explore risk factors associated with outcome.

[Emerging Microbes & Infections] Different T cell subpopulations have distinct characterizations and functions, and scientists revealed the high heterogeneity of susceptibility to viral infection and biological responses such as apoptosis in various CD4+ T and CD8+ T cell subsets through single-cell transcriptome analyses.

[Journal of Clinical Investigation] Scientists showed that human PD-1+Tim-3+ CD8+ tumor-infiltrating lymphocytes upregulated phosphatidylserine, a receptor for Tim-3, and acquire cell surface myeloid markers from antigen presenting cells through transfer of membrane fragments called trogocytosis.