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lymphoid cells

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Insulin Resistance in Diet-Induced Obese Mice via an Interaction with Splenocytes

[Stem Cell Research & Therapy] Human umbilical cord-derived MSCs infusions improved systemic metabolic homeostasis and alleviated insulin resistance in epididymal adipose tissue but elicited no change in weight.

Wugen Announces First Patient Dosed in Phase I/II Trial of WU-CART-007 for the Treatment of Patients with R/R T-ALL/LBL

[Wugen, Inc.] Wugen, Inc. announced that the first patient has been dosed in a Phase I/II trial of WU-CART-007 for the treatment of relapsed or refractory T cell acute lymphoblastic leukemia (T-ALL)/lymphoblastic lymphoma.

Major Histocompatibility Complex Class I Molecule Expression by Pancreatic Cancer Cells Is Regulated by Activation and Inhibition of the Epidermal Growth Factor Receptor

[Immunologic Research] In this current study, the authors discovered that epidermal growth factor receptor affected major histocompatibility complex class I mRNA and protein expression by human pancreatic cancer cell lines.

Transforming Growth Factor–β1 in Regulatory T Cell Biology

[Science Immunology] Investigators review transforming growth factor–β1 (TGF-β1) signaling in T regulatory cell (Treg) development and function and discuss knowledge gaps, future research, and the TGF-β1/Treg axis in the context of cancer immunotherapy and fibrosis.

A Three-Dimensional Immune-Oncology Model for Studying In Vitro Primary Human NK Cell Cytotoxic Activity

[PLoS One] Researchers described a simple and effective protocol to study the cytotoxic activity of primary human NK cells toward the 3D tumor spheroids.

A Pan-Genotype Hepatitis C Virus Viral Vector Vaccine Generates T Cells and Neutralizing Antibodies in Mice

[Hepatology] The authors showed that vaccinating with simian adenovirus vector encoding conserved sequences across gt1-6 and gt-1a E2 protein with variable regions deleted sequentially in mice generated T cell and antibody responses comparable to either vaccine given alone.

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